The above suggested air changes per hour are only a design rule of thumb.
Clean room design guide.
A clean room gmp cleanroom in my mind are a combination of engineering design fabrication finish and operational controls control strategy that are required to convert a normal room to a clean room.
A clean room explained in simple terms.
A basic design guide for clean room applications course content part i overview clean rooms are defined as specially constructed environmentally controlled enclosed spaces with respect to airborne particulates temperature humidity air pressure airflow patterns air motion vibration noise viable living organisms and lighting.
This design is generally thought to be the one to use for the optimum clean room but requires very stringent cleaning techniques done continually as part of the operating process in addition to specialized cleaning performed for each area in the cleanroom.
They should be computed by an hvac cleanroom expert as many aspects must be taken into consideration such as the size of the room the number of people in the room the equipment in the room the processes involved the heat gain etc.
Other posts about clean rooms.
Basic clean room requirements designs for gmp clean rooms what is a clean room.
A basic clean room.